| Identification | Back Directory | [Name]
BAY57-1293 mesylate | [CAS]
1428333-96-3 | [Synonyms]
AIC316 mesylate
Pritelivir mesylate
BAY57-1293 mesylate
Pritelivir mesylate (BAY 57-1293) | [Molecular Formula]
C19H22N4O6S3 | [MDL Number]
MFCD32671320 | [MOL File]
1428333-96-3.mol | [Molecular Weight]
498.59 |
| Hazard Information | Back Directory | [Uses]
BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor. | [in vivo]
Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3]. | Animal Model: | Female BALB/c mice[3] | | Dosage: | 0.03 to 45 mg/kg | | Administration: | Administered orally, twice daily at approximately 12 h intervals, for 7 days | | Result: | Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%. |
| [IC 50]
HSV-1: 0.02 μM (IC50); HSV-2: 0.02 μM (IC50) |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|