| Identification | Back Directory | [Name]
YH16899 | [CAS]
1428623-14-6 | [Synonyms]
YH16899
BC-K-YH16899
PMAMDXBXQJIVJC-BWAHOGKJSA-N
(Z)-2-(5,6-difluoro-2-((3-(trifluoromethyl)benzoyl)imino)benzo[d]thiazol-3(2H)-yl)butanoic acid | [Molecular Formula]
C19H13F5N2O3S | [MDL Number]
MFCD28160861 | [MOL File]
1428623-14-6.mol | [Molecular Weight]
444.38 |
| Hazard Information | Back Directory | [Description]
YH16899 is an inhibitor of the KRS-67LR interaction by directly blocking the association between KRS and 67LR, suppressing the dynamic movement of the N-terminal extension of KRS and reducing membrane localization of KRS. | [Uses]
YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models[1]. | [References]
[1] Kim DG, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014 Jan;10(1):29-34. DOI:10.1038/nchembio.1381 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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