| Identification | Back Directory | [Name]
IDF-11774 | [CAS]
1429054-28-3 | [Synonyms]
CS-2820
IDF-11774
IDF 11774;IDF11774
Ethanone, 1-(4-methyl-1-piperazinyl)-2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)- | [Molecular Formula]
C23H32N2O2 | [MDL Number]
MFCD31619285 | [MOL File]
1429054-28-3.mol | [Molecular Weight]
368.51 |
| Hazard Information | Back Directory | [Uses]
IDF-11774, is a novel hypoxia-inducible factor (HIF)-1 inhibitor with an IC50 of 3.65 μM in cancer cell line. It has shown to reduce capillary network formation on Matrigel, when human umbilical vascular endothelial cells (HUVECs) were treated with IDF-11774. | [in vivo]
Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control. When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model[1]. |
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