| Identification | Back Directory | [Name]
Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester | [CAS]
1429218-54-1 | [Synonyms]
Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester | [Molecular Formula]
C21H29N3O5 | [MOL File]
1429218-54-1.mol | [Molecular Weight]
403.47 |
| Hazard Information | Back Directory | [Description]
GC373 is a novel broad-spectrum antiviral against 3c or 3c-like proteases of picornaviruses, noroviruses, and coronaviruses | [Uses]
GC373 is a potent inhibitor of SARS-CoV-2 Mpro that blocks virus replication with an IC50 of 0.4 μM. CG373 can be utilized in anti-COVID-19 research[1]. | [References]
[1] Vuong W, et al. Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. Eur J Med Chem. 2021 Oct 15;222:113584. DOI:10.1016/j.ejmech.2021.113584 |
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