| Identification | Back Directory | [Name]
INCB-047775 | [CAS]
1430056-54-4 | [Synonyms]
AKT-IN-6
INCB-047775
1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl- | [Molecular Formula]
C22H20FN5O | [MDL Number]
MFCD30470660 | [MOL File]
1430056-54-4.mol | [Molecular Weight]
389.43 |
| Hazard Information | Back Directory | [Uses]
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). | [Biological Activity]
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2]. | [IC 50]
Akt1; Akt2; Akt3 | [storage]
Store at -20°C | [References]
[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1. [2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274. |
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