| Identification | Back Directory | [Name]
DBCO-S-S-PEG3-Biotin | [CAS]
1430408-09-5 | [Synonyms]
CAS_1430408-09-5
Biotin-PEG3-SS-DBCO
DBCO-S-S-PEG3-Biotin
Dibenzocyclooctyne-S-S-PEG3-Biotin
N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide | [Molecular Formula]
C42H56N6O8S3 | [MDL Number]
MFCD28334542 | [MOL File]
1430408-09-5.mol | [Molecular Weight]
869.12 |
| Chemical Properties | Back Directory | [Boiling point ]
1194.2±65.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [solubility ]
DMSO : 100 mg/mL (115.06 mM; Need ultrasonic) | [form ]
Oil | [pka]
13.90±0.40(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP. | [Uses]
DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-S-S-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
TCI Europe
|
| Tel: |
320-37350700 |
| Website: |
https://www.tcichemicals.com/de/de/index.html |
| Company Name: |
TCI AMERICA
|
| Tel: |
800-4238616 |
| Website: |
https://www.tcichemicals.com/en/us/index.html |
|