| Identification | Back Directory | [Name]
Urea, N-(2-hydroxyethyl)-N'-[6-(2-methoxyphenyl)-2-benzothiazolyl]- | [CAS]
1430720-10-7 | [Synonyms]
HS438
HS-438
HS 438
Urea, N-(2-hydroxyethyl)-N'-[6-(2-methoxyphenyl)-2-benzothiazolyl]- | [Molecular Formula]
C17H17N3O3S | [MOL File]
1430720-10-7.mol | [Molecular Weight]
343.4 |
| Hazard Information | Back Directory | [Description]
HS-438 is a novel inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. | [Uses]
HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML)[1]. | [References]
[1] Yun SM, et al. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Lett. 2014 Jun 28;348(1-2):50-60. DOI:10.1016/j.canlet.2014.03.012 |
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