| Identification | Back Directory | [Name]
FL442 | [CAS]
1431166-12-9 | [Synonyms]
FL442
Benzonitrile, 4-(3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-3-yl)-2-(trifluoromethyl)- | [Molecular Formula]
C15H13F3N2O | [MOL File]
1431166-12-9.mol | [Molecular Weight]
294.27 |
| Hazard Information | Back Directory | [Uses]
FL442 is an Androgen Receptor (AR) modulator. FL442 exhibits strong inhibitory effects in AR-dependent prostate cancer cells, showing similar inhibitory efficiency to traditional antiandrogen drugs Bicalutamide (HY-14249) and Enzalutamide (HY-70002), while maintaining antiandrogenic activity against the AR mutant F876L, which is highly resistant to Enzalutamide. Pharmacokinetic studies of FL442 in mice reveal a long half-life (8 hours), good targeting (prostate tissue), and metabolic stability, and it effectively inhibits LNCaP tumor growth at low plasma concentrations (30 ng/mL)[1]. | [References]
[1] Poutiainen PK, et al. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. Mol Cell Endocrinol. 2014 Apr 25;387(1-2):8-18. DOI:10.1016/j.mce.2014.02.008 |
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