| Identification | Back Directory | [Name]
ORY-1001(trans) | [CAS]
1431303-72-8 | [Synonyms]
Ladademstat
ORY-1001(trans)
ORY-1001 dihydrochloride
trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride | [Molecular Formula]
C15H23ClN2 | [MDL Number]
MFCD31807306 | [MOL File]
1431303-72-8.mol | [Molecular Weight]
266.81 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Water: 57.75 mg/mL (190.42 mM and warming); DMSO: 0.69 mg/mL (2.28 mM and warming) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. | [in vivo]
Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL[1]. | [References]
[1] Maes T, et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics. 2015;7(4):609-26. doi: 10.2217/epi.15.9. DOI:10.2217/epi.15.9
[2] Tamara Maes, et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. Cancer Cell. 2018 Mar 12;33(3):495-511.e12. DOI:10.1016/j.ccell.2018.02.002 |
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