| Identification | Back Directory | [Name]
2-(((1r,4r)-4-(2-amino-6-(6-methoxypyridin-3-yl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)cyclohexyl)oxy)acetic acid | [CAS]
1431626-44-6 | [Synonyms]
PF06465603
PF-06465603
PF 06465603
2-(((1r,4r)-4-(2-amino-6-(6-methoxypyridin-3-yl)-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)cyclohexyl)oxy)acetic acid | [Molecular Formula]
C22H25N5O5 | [MOL File]
1431626-44-6.mol | [Molecular Weight]
439.46 |
| Hazard Information | Back Directory | [Description]
PF-06465603 is a metabolite of PF-04691502 (MedKoo CAT#: 202226), a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR. | [Uses]
PF-06465603 is a highly potent and selective ATP-competitive kinase inhibitor and a class 1 PI3K and mTOR inhibitor. PF-06465603 is a metabolite of PF-04691502 with a terminal carboxylic acid structure[1]. | [References]
[1] Structure-based design, SAR analysis and antitumor activity of PI3K/ mTOR dual inhibitors from 4-methylpyridopyrimidinone series |
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