| Identification | Back Directory | [Name]
2-Pyrrolidinemethanol, 1-methyl-, 2-benzoate, (2S)- | [CAS]
1431628-22-6 | [Synonyms]
(S)-UFR2709
(2S)?-1-?Methyl-?2-?pyrrolidinemethanol 2-?Benzoate
2-Pyrrolidinemethanol, 1-methyl-, 2-benzoate, (2S)- | [Molecular Formula]
C13H17NO2 | [MOL File]
1431628-22-6.mol | [Molecular Weight]
219.28 |
| Hazard Information | Back Directory | [Uses]
(2S)?-1-?Methyl-?2-?pyrrolidinemethanol 2-?Benzoate could be useful as a selective antagonist for human α4β2 nicotinic acetylcholine receptors. | [in vivo]
(S)-UFR2709 (50-100 μg/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 μg/ml[2].(S)-UFR2709 (50-100 μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit, but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish[2].(S)-UFR2709 (intraperitoneal?injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption.?(S)-UFR2709 does not affect the weight or locomotor activity of the rats[1]. | Animal Model: | High-alcohol-drinking UChB rats[1] | | Dosage: | 10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg | | Administration: | Intraperitoneal?injection; 1-10 mg/kg; daily; 17 days | | Result: | Did not affect the weight or locomotor activity and reduced ethanol consumption and preference. |
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