| Identification | Back Directory | [Name]
KN-92 (hydrochloride) | [CAS]
1431698-47-3 | [Synonyms]
CS-1448
KN92-HCl
KN-92 (hydrochloride)
KN 92 HYDROCHLORIDE; KN92 HYDROCHLORIDE | [Molecular Formula]
C24H26Cl2N2O3S | [MDL Number]
MFCD25372041 | [MOL File]
1431698-47-3.mol | [Molecular Weight]
493.446 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
≥24.65 mg/mL in DMSO; insoluble in H2O; ≥11.73 mg/mL in EtOH with gentle warming and ultrasonic | [form ]
solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
kn-92 is an inactive analog of kn-93. kn-93 is the cam kinase ii inhibitor. [1]hearts were treated with the cam kinase inhibitor kn-93 or the inactive analog kn-92 (0.5 μm) for 10 min before clofilium exposure. early afterdepolarizations (eads) were largely inhibited by kn-93 contrasted to kn-92. there were little differences in parameters favoring eads such as monophasic action potential duration or heart rate in kn-92- or kn-93- treated hearts. cam kinase activity in situ increased 37% in hearts with eads compared to hearts without eads. this increase in cam kinase activity was prevented by pretreatment with kn-93. [1]in vitro, kn-93 potently suppressed rabbit myocardial cam kinase activity (calculated ki ≤ 2.58 μm), but the inactive analog kn-92 did not (ki > 100 μm). the actions of kn-93 and kn-92 on ica and other repolarizing k+currents did not illustrate preferential ead suppression by kn-93. [1] | [References]
1. kn-93, an inhibitor of multifunctional ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. j pharmacol exp ther. 1998 dec;287(3):996-1006. |
|
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|