| Identification | Back Directory | [Name]
L-Thyroxine-13C9,15N | [CAS]
1431868-11-9 | [Synonyms]
L-Thyroxine-13C9,15N
Levothyroxine-13C9-15N
Thyroxine Carboxy,α,β,1,2,3,4,5,6-13C9,15N | [Molecular Formula]
C15H11I4NO4 | [MOL File]
1431868-11-9.mol | [Molecular Weight]
786.96 |
| Chemical Properties | Back Directory | [density ]
2.636±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 0.14 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml | [form ]
A solid |
| Hazard Information | Back Directory | [Description]
L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism. | [Uses]
Thyroxine Carboxy,α,β,1,2,3,4,5,6-13C9,15N is 13C and 15N labeled analogue of Thyroxine (T425600), which is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. | [in vivo]
Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion[2]. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03)[3]. |
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