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143360-00-3

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143360-00-3 Structure

143360-00-3 Structure
IdentificationBack Directory
[Name]

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
[CAS]

143360-00-3
[Synonyms]

SMIP004
CS-1090
SMIP-004
SMIP 004
SMIP 004; SMIP-004
4-N-BUTYL-2-METHYLACETANILIDE
4'-(But-1-yl)-2'-methylacetanilide
N-(4-Butyl-2-methylphenyl)acetamide
N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
Acetamide, N-(4-butyl-2-methylphenyl)-
N-[4-(But-1-yl)-2-methylphenyl]acetamide, 2-Acetamido-5-(but-1-yl)toluene
[Molecular Formula]

C13H19NO
[MDL Number]

MFCD00277686
[MOL File]

143360-00-3.mol
[Molecular Weight]

205.3
Chemical PropertiesBack Directory
[Boiling point ]

343.0±21.0 °C(Predicted)
[density ]

1.003±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic
[form ]

Solid
[pka]

15.14±0.70(Predicted)
[color ]

White to off-white
[InChI]

1S/C13H19NO/c1-4-5-6-12-7-8-13(10(2)9-12)14-11(3)15/h7-9H,4-6H2,1-3H3,(H,14,15)
[InChIKey]

ZFVMECVBUGMWIX-UHFFFAOYSA-N
[SMILES]

N(c1c(cc(cc1)CCCC)C)C(=O)C
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302+H312+H332-H315-H319-H335
[Precautionary statements ]

P280
[WGK Germany ]

WGK 2
[HS Code ]

2924297099
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].
[Biological Activity]

Cell permeable: yes''Reversible: yes
[in vivo]

SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2].

[storage]

Store at -20°C
[References]

[1] Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. DOI:10.1186/s13046-019-1069-3
[2] Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14. DOI:10.18632/oncotarget.1130
Spectrum DetailBack Directory
[Spectrum Detail]

N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE(143360-00-3)1HNMR
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