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143413-49-4

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143413-49-4 Structure

143413-49-4 Structure
IdentificationBack Directory
[Name]

ALX 40-4C
[CAS]

143413-49-4
[Synonyms]

ALX 40-4C
D-Argininamide, N2-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl- (9CI)
[Molecular Formula]

C56H113N37O10
[MDL Number]

MFCD31630715
[MOL File]

143413-49-4.mol
[Molecular Weight]

1464.74
Chemical PropertiesBack Directory
[density ]

1.58±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.
[IC 50]

SDF-1-CXCR4: 1 μM (Ki); APJ receptor: 2.9 μM (IC50)
[storage]

Store at -20°C
[References]

[1] Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86. DOI:10.1089/08892220151126508
[2] Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. DOI:10.1016/s0166-3542(03)00071-8
[3] Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. DOI:10.1016/s0042-6822(03)00185-5
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