| Hazard Information | Back Directory | [Description]
Merodantoin, also known as compound C1, is an apoptosis inducer, triggering ROS dependent autophagy-associated apoptosis in a variety of human cancer cell lines and against mutant KRAS expressing cancer cells involving AKT-dependent ROS production. | [Uses]
Merodantoin has significant antitumor activity in vitro and in vivo, and has less toxicity to normal cells and tissues[1]. | [Definition]
ChEBI: 1,3-dibutyl-2-sulfanylideneimidazolidine-4,5-dione is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid. | [References]
[1] Gulliya KS, et al. Topoisomerase II-dependent novel antitumor compounds merocil and merodantoin induce apoptosis in Daudi cells. Anticancer Drugs. 1994 Oct;5(5):557-66. DOI:10.1097/00001813-199410000-00007 |
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