| Identification | Back Directory | [Name]
Ethanol, 2-[[3-methoxy-2-propoxy-5-[(2R,5R)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]sulfonyl]- | [CAS]
143490-81-7 | [Synonyms]
L-680573
L-680573, (R,R)-
L 680573, (R,R) ,L680573, (R,R)
Ethanol, 2-[[3-methoxy-2-propoxy-5-[(2R,5R)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]sulfonyl]- | [Molecular Formula]
C25H34O9S | [MOL File]
143490-81-7.mol | [Molecular Weight]
510.6 |
| Hazard Information | Back Directory | [Uses]
(R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM) and elastase release from PMNs (ED50=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg)[1]. | [References]
[1] Hwang S B, et al. MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor[J]. Journal of lipid mediators, 1993, 7(2): 115-134. PMID:8400114 |
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