| Identification | Back Directory | [Name]
1-hydrazino-3-(methylthio)propan-2-ol | [CAS]
14359-97-8 | [Synonyms]
Nifuratel-4
Einecs 238-332-5
Nifuratel impurity H
Nifuratel Impurity 9
Nifuratel NFT3 Intermediate
1-Hydrazino-3-methylthio-2-propanol
1-hydrazino-3-(methylthio)propan-2-ol
2-propanol,1-hydrazinyl-3-(methylthio)
1-hydrazinyl-3-(Methylthio)-2-Propanol
1-hydrazinyl-3-(methylthio)propan-2-ol
1-hydrazinyl-3-methylsulfanylpropan-2-ol | [EINECS(EC#)]
238-332-5 | [Molecular Formula]
C4H12N2OS | [MDL Number]
MFCD13152171 | [MOL File]
14359-97-8.mol | [Molecular Weight]
136.22 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
1-hydrazino-3-(methylthio)propan-2-ol, also known as 3-methylmercapto-2-hydroxy-propyl hydrazine, is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. It can be used to synthesize N-amino-5-methylmercapto-methyl-2-oxazolidinone which is an intermediate of nifuratel.
| [Synthesis]
Add 226.25g hydrazine hydrate to 1000ml reaction flask, heat to 90℃, and add 104.17g of glycidyl ether under stirring. The temperature of the reaction system was controlled at 90℃, and then the excess hydrazine hydrate was concentrated under reduced pressure to obtain 120.10g thick colorless liquid. The purity of the gas phase was 96.8%, namely 1-hydrazino-3-(methylthio)propan-2-ol, and the yield was 88.30%.
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