| Identification | Back Directory | [Name]
3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE | [CAS]
143591-61-1 | [Synonyms]
3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE
8-Chloro-3-bromoimidazo[1,2-a]pyrazine
Imidazo[1,2-a]pyrazine, 3-bromo-8-chloro- | [Molecular Formula]
C6H3BrClN3 | [MDL Number]
MFCD09909653 | [MOL File]
143591-61-1.mol | [Molecular Weight]
232.47 |
| Chemical Properties | Back Directory | [density ]
2.03±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
-1.45±0.30(Predicted) | [Appearance]
Off-white to light brown Solid | [InChI]
InChI=1S/C6H3BrClN3/c7-4-3-10-6-5(8)9-1-2-11(4)6/h1-3H | [InChIKey]
MCEGPQSPRNOFMG-UHFFFAOYSA-N | [SMILES]
C12=NC=C(Br)N1C=CN=C2Cl |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-bromo-8-chloroimidazo[1,2-a]pyrazine from 8-chloroimidazo[1,2-a]pyrazine: N-bromosuccinimide (1.78 g, 10 mmol) was added to a solution of 8-chloroimidazo[1,2-a]pyrazine (1.53 g, 10 mmol) in dichloromethane (30 mL), and the reaction was stirred for 2 hours at room temperature. After the reaction was completed, the reaction mixture was washed with saturated aqueous sodium carbonate solution (2×20 mL), dried with anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 3-bromo-8-chloroimidazo[1,2-a]pyrazine (2.11 g, 96% yield). | [References]
[1] Patent: WO2009/24585, 2009, A2. Location in patent: Page/Page column 46
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1582 - 1585
[3] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 623 - 643
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5170 - 5174
[5] Patent: WO2012/80229, 2012, A1. Location in patent: Page/Page column 40 |
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