| Identification | Back Directory | [Name]
1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- | [CAS]
1436695-49-6 | [Synonyms]
VMAT2INI HCl
VMAT2-IN-I HCl
VMAT2 IN I HCl
VMAT2INI Hydrochloride
VMAT2-IN-I Hydrochloride
VMAT2 IN I Hydrochloride
1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- | [Molecular Formula]
C25H32ClF4NO4 | [MOL File]
1436695-49-6.mol | [Molecular Weight]
521.98 |
| Hazard Information | Back Directory | [Description]
VMAT2-IN-I HCl is a vesicular monoamine transporter-2 (VMAT2) inhibitor, with 15-?fold greater affinity than GZ-?793A. | [Uses]
VMAT2-IN-4 (compound 11) is a vesicular monoamine transporter-2 (VMAT2) inhibitor. VMAT2-IN-4 inhibits [3H]-DTBZ binding (Ki = 560 nM). VMAT2-IN-4 inhibits [3H]-DA (Ki = 45 nM) from entering vesicles and being taken up by cells. VMAT2-IN-4 can be used in methamphetamine addiction research[1]. | [IC 50]
VMAT2 | [References]
[1] Penthala NR, et al. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorg Med Chem Lett. 2013 Jun 1;23(11):3342-5. DOI:10.1016/j.bmcl.2013.03.092 |
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