ChemicalBook--->CAS DataBase List--->1437321-24-8

1437321-24-8

1437321-24-8 Structure

1437321-24-8 Structure
IdentificationBack Directory
[Name]

CEP-40783
[CAS]

1437321-24-8
[Synonyms]

CS-2528
RXDX-106
CEP-40783
CEP-40783(RXDX-106)
RXDX-106(CEP-40783)
CEP 40783; CEP40783; RXDX-106
3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]amide
5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-
[Molecular Formula]

C31H26F2N4O6
[MDL Number]

MFCD28502441
[MOL File]

1437321-24-8.mol
[Molecular Weight]

588.56
Chemical PropertiesBack Directory
[density ]

1.394±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF:20.0(Max Conc. mg/mL);33.89(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.51(Max Conc. mM)
DMSO:6.04(Max Conc. mg/mL);10.26(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);3.4(Max Conc. mM)
[form ]

A crystalline solid
[pka]

10.42±0.70(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P280-P305+P351+P338
Hazard InformationBack Directory
[Uses]

CEP-40783 is a potent, selective and orally potent inhibitor of axl and c-Met with IC50 values of 7nM and 12nM, respectively.
[Biological Activity]

RXDX-106 (CEP-40783) is an orally available, potent, and selective inhibitor of TAM (TYRO3, AXL, MER)/Met (c-Met), with low levels in peptide phosphorylation assays. Nanomolar biochemical activity; slow dissociation rate (T1/2 >120 min) in in vitro kinase binding assays.
[in vitro]

CEP-40783 inhibited TAM and c-MET phosphorylation, accompanied by a decrease in downstream MAPK and PI3K signaling and cellular activity. In TAM-expressing cells, sub-nanomolar concentrations of RXDX-106 completely inhibited cell proliferation and cell viability.

[in vivo]

CEP-40783 inhibits tumors with activating TAM gene fusions and affects the TAM-expressing tumor microenvironment, resulting in an overall anticancer environment.
[target]

TargetValue
Axl
(Cell-free assay)
7 nM
c-Met
(Cell-free assay)
12 nM
Tyro3
(Cell-free assay)
19 nM
MER
(Cell-free assay)
29 nM
Tyro3
(Cell-free assay)
29 nM
Spectrum DetailBack Directory
[Spectrum Detail]

CEP-40783(1437321-24-8)1HNMR
1437321-24-8 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: Baoji Guokang Healthchem co.,ltd
Tel: +8615604608665 15604608665 , 15604608665
Website: www.gk-bio.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +86-512-68323658 +86-18168183658 , +86-18168183658
Website:
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Dongyang Biotechnology Co., Ltd.  Gold
Tel: 0512-0512-13601744364 13601744364
Website: www.chemicalbook.com/showsupplierproductslist1201937/0.htm
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Website: https://www.bocsci.com
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Website: www.caerulumpharma.com
Company Name: Hefei Yucheng Pharmaceutical Technology Co., Ltd.  
Tel: 15385513552
Website: https://www.chemicalbook.com/ShowSupplierProductsList16366/0.htm
Company Name: Hangzhou J&H Chemical Co., Ltd.  
Tel: 0571-+86-571-87396432
Website: www.jhechem.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696,15000506266 15000506266
Website: http://www.bioll.com
Company Name: Shanghaizehan biopharma technology co., Ltd.  
Tel: 021-61350663 13052117465
Website: http://www.zehanbiopharma.com
Company Name: INTERCHEMIE NANJING PHARMATECH CO., LTD  
Tel: 13656237714 13656237714
Website: https://www.chemicalbook.com/ShowSupplierProductsList19089/0.htm
Tags:1437321-24-8 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.