| Identification | Back Directory | [Name]
Lu 26-046 | [CAS]
143756-51-8 | [Synonyms]
Lu 26-046
Isothiazolo[4,5-c]pyridine, 4,5,6,7-tetrahydro-7-methyl-3-(2-propyn-1-yloxy)-, (7R)- | [Molecular Formula]
C10H12N2OS | [MOL File]
143756-51-8.mol | [Molecular Weight]
208.28 |
| Hazard Information | Back Directory | [Description]
Lu 26-046 is a muscarinic receptor agonist. | [Uses]
Lu 26-046 is the agonist for muscarinic M1 receptor and M2 receptor and a weak antagonist for M3 receptor, with Ki of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats[1]. | [IC 50]
mAChR1: 0.51 nM (Ki); mAChR3: 5 nM (Ki); mAChR2: 26 nM (Ki) | [References]
[1] Arnt J, et al., Discriminative stimulus properties of the muscarinic receptor agonists Lu 26-046 and O-Me-THPO in rats: evidence for involvement of different muscarinic receptor subtypes. Eur J Pharmacol. 1992 Jul 21;218(1):159-69. DOI:10.1016/0014-2999(92)90160-6 |
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