| Identification | Back Directory | [Name]
Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- | [CAS]
1438280-73-9 | [Synonyms]
Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- | [Molecular Formula]
C25H26N4O2S | [MOL File]
1438280-73-9.mol | [Molecular Weight]
446.56 |
| Hazard Information | Back Directory | [Uses]
1Z105 is an oral active TLR4/MD2 ligand. 1Z105 enhances dendritic cell maturation and antigen presentation and prevents rthritis[1][2]. | [References]
[1] Goff PH, et al. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015;89(6):3221-3235. DOI:10.1128/JVI.03337-14
[2] Hayashi T, et al. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014;350(2):330-340. DOI:10.1124/jpet.114.214312 |
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