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1440126-94-2

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1440126-94-2 Structure

1440126-94-2 Structure
IdentificationBack Directory
[Name]

Pyrimidyn-7
[CAS]

1440126-94-2
[Synonyms]

Pyrimidyn-7
2,4-Pyrimidinediamine, N2-[2-(dimethylamino)ethyl]-N4-dodecyl-6-methyl-
[Molecular Formula]

C21H41N5
[MOL File]

1440126-94-2.mol
[Molecular Weight]

363.58
Chemical PropertiesBack Directory
[Boiling point ]

506.5±60.0 °C(Predicted)
[density ]

0.984±0.06 g/cm3(Predicted)
[pka]

9.05±0.28(Predicted)
Hazard InformationBack Directory
[Uses]

Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell[1.
[References]

[1] McGeachie AB, et al. Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. ACS Chem Biol. 2013 Jul 19;8(7):1507-18. DOI:10.1021/cb400137p
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