| Identification | Back Directory | [Name]
Pyrimidyn-7 | [CAS]
1440126-94-2 | [Synonyms]
Pyrimidyn-7
2,4-Pyrimidinediamine, N2-[2-(dimethylamino)ethyl]-N4-dodecyl-6-methyl- | [Molecular Formula]
C21H41N5 | [MOL File]
1440126-94-2.mol | [Molecular Weight]
363.58 |
| Hazard Information | Back Directory | [Uses]
Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell[1. | [References]
[1] McGeachie AB, et al. Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. ACS Chem Biol. 2013 Jul 19;8(7):1507-18. DOI:10.1021/cb400137p |
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