| Identification | Back Directory | [Name]
1-Piperidineethanol, 4-(1-pyrrolidinyl)-α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- | [CAS]
1440532-33-1 | [Synonyms]
TWIK-1/TREK-1-IN-3
1-Piperidineethanol, 4-(1-pyrrolidinyl)-α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- | [Molecular Formula]
C19H27F3N2O2 | [MOL File]
1440532-33-1.mol | [Molecular Weight]
372.43 |
| Chemical Properties | Back Directory | [Boiling point ]
477.6±45.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.95±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1]. | [References]
[1] Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. . DOI:10.1016/j.biopha.2023.115139 |
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