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1440964-89-5

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1440964-89-5 Structure

1440964-89-5 Structure
IdentificationBack Directory
[Name]

PLB-1001
[CAS]

1440964-89-5
[Synonyms]

CBT-101
BOZITINIB
PLB-1001
BOZITINIB (PLB-1001)
1,2,4-Triazolo[4,3-b]pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-[difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl]-
[Molecular Formula]

C20H15F3N8
[MOL File]

1440964-89-5.mol
[Molecular Weight]

424.38
Chemical PropertiesBack Directory
[density ]

1.68±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 50 mg/mL (117.82 mM)
[form ]

Solid
[pka]

0.15±0.12(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily[1].
[References]

[1] Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18. DOI:10.1016/j.cell.2018.09.038
Spectrum DetailBack Directory
[Spectrum Detail]

PLB-1001 (1440964-89-5)1HNMR
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