| Identification | Back Directory | [Name]
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- | [CAS]
1441961-74-5 | [Synonyms]
A1AR antagonist 2
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- | [Molecular Formula]
C17H12N4O | [MOL File]
1441961-74-5.mol | [Molecular Weight]
288.3 |
| Hazard Information | Back Directory | [Uses]
A1AR antagonist 2 (compound 18h) is a potent A1 adenosine receptor (AR) antagonist with Kis of 1.49, 10.2, and 50.1 nM for hA1, hA2A and hA2B, respectively[1]. | [References]
[1] Val C, et al. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists. J Med Chem. 2022;65(3):2091-2106. DOI:10.1021/acs.jmedchem.1c01636 |
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