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1442106-10-6

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1442106-10-6 Structure

1442106-10-6 Structure
IdentificationBack Directory
[Name]

MM-401
[CAS]

1442106-10-6
[Synonyms]

MM-401
MM-401(MM 401
N-[(3R,9S,12R)-9-[3-(diaminomethylideneamino)propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide
[Molecular Formula]

C29H46N8O5
[MOL File]

1442106-10-6.mol
[Molecular Weight]

586.73
Chemical PropertiesBack Directory
[density ]

1.29±0.1 g/cm3(Predicted)
[pka]

12.78±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1].
[References]

[1] Fang Cao, et al. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell. 2014 Jan 23;53(2):247-61. DOI:10.1016/j.molcel.2013.12.001
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