| Identification | Back Directory | [Name]
L-Methionine, N-[(2S)-2-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]- | [CAS]
144505-58-8 | [Synonyms]
SCH-42354
L-Methionine, N-[(2S)-2-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]- | [Molecular Formula]
C16H23NO3S2 | [MOL File]
144505-58-8.mol | [Molecular Weight]
341.49 |
| Hazard Information | Back Directory | [Uses]
SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2]. | [References]
[1] Thompson JS, et, al. Neutral endopeptidase inhibition increases the potency of ANP in isolated rat pulmonary resistance vessels and isolated blood perfused lungs. Pulm Pharmacol. 1995 Apr-Jun;8(2-3):143-7. DOI:10.1006/pulp.1995.1018
[2] Watkins RW, et, al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. DOI:10.1093/ajh/6.5.357 |
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