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1445251-22-8

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1445251-22-8 Structure

1445251-22-8 Structure
IdentificationBack Directory
[Name]

ME0328
[CAS]

1445251-22-8
[Synonyms]

ME0328
ME0328 USP/EP/BP
4-Dihydro-4-oxo-3
ME0328; ME 0328; ME-0328
4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-
3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
[EINECS(EC#)]

808-923-8
[Molecular Formula]

C19H19N3O2
[MDL Number]

MFCD27991291
[MOL File]

1445251-22-8.mol
[Molecular Weight]

321.373
Chemical PropertiesBack Directory
[storage temp. ]

room temp
[solubility ]

DMSO: soluble10mg/mL, clear
[form ]

powder
[color ]

white to beige
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
[InChI]

1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
[InChIKey]

QIHBWVVVRYYYRO-ZDUSSCGKSA-N
[SMILES]

[nH]1c2c([c](nc1CCC(=O)N[C@@H](C)c3ccccc3)=O)cccc2
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-43
[Safety Statements ]

36/37
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Description]

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.
[Uses]

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.
[IC 50]

ARTD3/PARP3: 0.89 μM (IC50); ARTD1/PARP1: 6.3 μM (IC50); ARTD2/PARP2: 10.8 μM (IC50); ARTD6/TNKS2: 34.3 μM (IC50); ARTD5/TNKS1: 47.3 μM (IC50); ARTD10/PARP10: 71.3 μM (IC50)
[References]

1) Lindgren?et al. (2013),?PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ART3/PARP3; ACS Chem. Biol.,8?1689
Spectrum DetailBack Directory
[Spectrum Detail]

ME0328(1445251-22-8)1HNMR
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