| Identification | Back Directory | [Name]
SQUALESTATIN | [CAS]
144541-82-2 | [Synonyms]
L-694,599
SQUALESTATIN
ZARAGOZIC ACID A SODIUM SALT
Zaragozic acid A trisodium salt | [Molecular Formula]
C35H47NaO14 | [MDL Number]
MFCD03788025 | [MOL File]
144541-82-2.mol | [Molecular Weight]
714.74 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 9.80-10.20mg/mL, clear, colorless to faintly yellow | [form ]
lyophilized powder | [biological source]
microbial |
| Hazard Information | Back Directory | [Uses]
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
| [Uses]
Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase. | [Biochem/physiol Actions]
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels. |
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