| Identification | Back Directory | [Name]
Belvarafenib | [CAS]
1446113-23-0 | [Synonyms]
Belvarafenib
4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
Thieno[3,2-d]pyrimidine-7-carboxamide, 4-amino-N-[1-[(3-chloro-2-fluorophenyl)amino]-6-methyl-5-isoquinolinyl]- | [Molecular Formula]
C23H16ClFN6OS | [MDL Number]
MFCD31731098 | [MOL File]
1446113-23-0.mol | [Molecular Weight]
478.93 |
| Chemical Properties | Back Directory | [Boiling point ]
609.6±55.0 °C(Predicted) | [density ]
1.562±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:46.17(Max Conc. mg/mL);96.4(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.64(Max Conc. mM) | [form ]
A crystalline solid | [pka]
11.16±0.43(Predicted) | [color ]
Off-white to yellow | [InChIKey]
KVCQTKNUUQOELD-UHFFFAOYSA-N | [SMILES]
C1=NC(N)=C2SC=C(C(NC3=C(C)C=CC4=C3C=CN=C4NC3=CC=CC(Cl)=C3F)=O)C2=N1 |
| Hazard Information | Back Directory | [Uses]
Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1]. | [IC 50]
BRafV600E: 7 nM (IC50); CRAF: 5 nM (IC50); B-Raf: 56 nM (IC50) | [References]
[1] WO 2013/100632 A1. |
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