| Identification | Back Directory | [Name]
1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1'-biphenyl]-4-yl]methyl]- | [CAS]
144628-52-4 | [Synonyms]
HR720
HR-720
HOE720
HOE-720
Fonsartan free acid
1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1'-biphenyl]-4-yl]methyl]- | [Molecular Formula]
C26H32N4O5S2 | [MOL File]
144628-52-4.mol | [Molecular Weight]
544.69 |
| Hazard Information | Back Directory | [Uses]
Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases[1]. | [References]
[1] Deprez P, et al. Sulfonylureas and sulfonylcarbamates as new non-tetrazole angiotensin II receptor antagonists. Discovery of a highly potent orally active (imidazolylbiphenylyl)sulfonylurea (HR 720). J Med Chem. 1995 Jun 23;38(13):2357-77. DOI:10.1021/jm00013a013 |
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