| Identification | Back Directory | [Name]
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester | [CAS]
1446282-35-4 | [Synonyms]
C6-Bis-phosphoramidic acid diethyl ester
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester | [Molecular Formula]
C14H34N2O8P2 | [MDL Number]
MFCD25424109 | [MOL File]
1446282-35-4.mol | [Molecular Weight]
420.376 |
| Hazard Information | Back Directory | [Uses]
C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
Alkyl-Chain | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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