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1446282-35-4

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1446282-35-4 Structure

1446282-35-4 Structure
IdentificationBack Directory
[Name]

[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester
[CAS]

1446282-35-4
[Synonyms]

C6-Bis-phosphoramidic acid diethyl ester
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester
[Molecular Formula]

C14H34N2O8P2
[MDL Number]

MFCD25424109
[MOL File]

1446282-35-4.mol
[Molecular Weight]

420.376
Chemical PropertiesBack Directory
[Boiling point ]

442.2±55.0 °C(Predicted)
[density ]

1.106±0.06 g/cm3(Predicted)
[pka]

2.06±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

Alkyl-Chain
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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