| Identification | Back Directory | [Name]
2-(4-Bromo-2-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine | [CAS]
1447968-71-9 | [Synonyms]
BMS-986124
BMS-986124 >=98% (HPLC)
2-(4-Bromo-2-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine
Thiazolidine, 2-(4-bromo-2-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]- | [Molecular Formula]
C16H15BrClNO3S2 | [MDL Number]
MFCD28009506 | [MOL File]
1447968-71-9.mol | [Molecular Weight]
448.78 |
| Chemical Properties | Back Directory | [Boiling point ]
555.0±60.0 °C(Predicted) | [density ]
1.586±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
-8.89±0.40(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
BMS-986124 is a μ-opioid receptor silent allosteric modulator (μ-SAMs). BMS-986124 antagonizes positive allosteric modulator effect of BMS-986122 (μ-OR PAM)[1]. | [Biological Activity]
BMS-986124 is a silent allosteric modulator (SAM) of the m-opioid receptor (MOR). The compound BMS-986124 blocks the effects of the MOR positive allosteric modulator BMS-986122but does not affect binding or activities of orthosteric MOR agonists such as endomorphin-I or DAMGO. | [References]
[1] Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. DOI:10.1073/pnas.1300393110 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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