| Identification | Back Directory | [Name]
(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide | [CAS]
1448440-52-5 | [Synonyms]
CS-2845
SP-13786
UAMC-1110
(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
(S)-N-[2-(2-Cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]quinoline-4-carboxamide
4-Quinolinecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide (UAMC1110) | [Molecular Formula]
C17H14F2N4O2 | [MDL Number]
MFCD29477499 | [MOL File]
1448440-52-5.mol | [Molecular Weight]
344.32 |
| Chemical Properties | Back Directory | [Melting point ]
>70°C (Decomposed) | [Boiling point ]
676.4±55.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
12.43±0.46(Predicted) | [color ]
Off-White to Pale Yellow | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1 | [InChIKey]
PUOOCZVRHBHJRS-NSHDSACASA-N | [SMILES]
N1C2C(=CC=CC=2)C(C(NCC(N2CC(F)(F)C[C@H]2C#N)=O)=O)=CC=1 |
| Hazard Information | Back Directory | [Uses]
UAMC1110 is a useful research chemical and a fibroblast activation protein inhibitor displaying low nanomolar inhibitory potency and high selectivity against related dipeptidyl peptidases. | [in vivo]
UAMC-1110 is the most extensive and prolonged inhibitior of FAP in the PK studies. Pharmacokinetic evaluation in mice of UAMC-1110 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo[1]. |
|
|