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TP receptor antagonist-1 (compound 7m) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease[1]. | [IC 50]
Thromboxane A2 receptor α (TPa): 9.46 μM (IC50); Thromboxane A2 receptor β (TPb): 8.49 μM (IC50) | [References]
[1] Bambi-Nyanguile SM, et al. Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A? receptor antagonists. Eur J Med Chem. 2013 Jul;65:32-40. DOI:10.1016/j.ejmech.2013.04.033 |
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