| Hazard Information | Back Directory | [Uses]
5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1]. | [in vivo]
5-HT7R antagonist (compound 4h) (intraperitoneal injection, 5 mg/kg, 30 min) has the potential to regulate the repetitive behavior of ASD in the animal model of ASD, and can increase the number of immature ASD neurons[1].
| Animal Model: | ASD animal models | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneal injection | | Result: | 4h can increase the number of immature ASD neurons |
| [IC 50]
5-HT7 Receptor: 67 nM (Ki) | [References]
[1] Jeong JH, et al. Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R. ACS Chem Neurosci. 2024;15(5):1026-1041. DOI:10.1021/acschemneuro.3c00738 |
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