| Identification | Back Directory | [Name]
K145 (hydrochloride) | [CAS]
1449240-68-9 | [Synonyms]
K145(HCl)
SphK2 inhibitor
K14 (hydrochloride)
K145 (hydrochloride)
K145 hydrochloride >=98% (HPLC)
SPHK2 INHIBITOR;K 145 HYDROCHLORIDE;K-145 HYDROCHLORIDE
3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1) | [Molecular Formula]
C18H25ClN2O3S | [MDL Number]
MFCD28160629 | [MOL File]
1449240-68-9.mol | [Molecular Weight]
384.921 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-; | [InChIKey]
HADFDMGQKBGVAV-NKBLJONXSA-N | [SMILES]
S1\C(=C/CCc2ccc(cc2)OCCCC)\C(=O)N(C1=O)CCN.Cl |
| Hazard Information | Back Directory | [Uses]
K145 hydrochloride has been used in the analysis of apoptosis. | [General Description]
K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine. | [Biochem/physiol Actions]
It has the ability to prevent leukemia cell growth in vitro. | [in vivo]
K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice[1]. | Animal Model: | BALB/c-nu mice injected with U937 cells[1] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage; daily; for 15 days | | Result: | Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.
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| [IC 50]
SphK2 |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|