| Hazard Information | Back Directory | [Description]
ZYJ-34v is an oral active histone deacetylase inhibitor with potent antitumor activity. | [Uses]
ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity[1]. | [in vivo]
ZYJ-34v (90 mg/kg, orally, for 22 days) shows antitumor activity in MDA-MB-231 xenograft tumor model[1].
| Animal Model: | a mouse MDA-MB-231 xenograft model[1] | | Dosage: | 90 mg/kg | | Administration: | p.o. | | Result: | Decreased the final tumor volume. |
| [References]
[1] Zhang Y, et al. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem Biol Drug Des. 2013 Aug;82(2):125-30. DOI:10.1111/cbdd.12144 |
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