| Identification | Back Directory | [Name]
RU 47213 | [CAS]
145071-44-9 | [Synonyms]
RU 47213
Brn 5822162
4-Chlorophenyl (E)-3,6-dihydro-5-((methoxyimino)methyl)-1(2H)-pyridinecarboxylate
1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-((methoxyimino)methyl)-, 4-chlorophenyl ester, (E)- | [Molecular Formula]
C14H15ClN2O3 | [MDL Number]
MFCD00867214 | [MOL File]
145071-44-9.mol | [Molecular Weight]
294.733 |
| Hazard Information | Back Directory | [Description]
RU 47213 is a novel oral and long-lasting cholinomimetic agent. | [Uses]
Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat[1]. | [References]
[1] M M'Harzi, et al. Ameliorating effects of RU 47213, a novel oral and long-lasting cholinomimetic agent, on working memory impairments in rats. Pharmacol Biochem Behav. 1997 Apr;56(4):663-8. DOI:10.1016/s0091-3057(96)00423-6 |
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