| Identification | Back Directory | [Name]
ALRN6924 | [CAS]
1451199-98-6 | [Synonyms]
ALRN6924
Sulanemadlin
D-Alaninamide, 42,112-(7E)-7-undecene-1,11-diyl-N-acetyl-L-leucyl-L-threonyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-leucyl-D-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl- | [Molecular Formula]
C95H140N20O23 | [MOL File]
1451199-98-6.mol | [Molecular Weight]
1930.28 |
| Chemical Properties | Back Directory | [Boiling point ]
2087.7±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.48±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ac-Leu-Thr-Phe-Ala-Glu-Tyr-Trp-Ala-Gln-Leu-R8-Ala-Ala-Ala-Ala-Ala-S5-NH2 (stapled ring: R8-S5) |
| Hazard Information | Back Directory | [Uses]
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research[1]. | [References]
[1] Manuel AIVADO, et al. Peptidomimetic macrocycles and uses thereof. WO2018208954A2 |
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