| Identification | Back Directory | [Name]
KAN0438757 | [CAS]
1451255-59-6 | [Synonyms]
KAN0438757
Benzoic acid, 4-[[(5'-fluoro-2'-hydroxy[1,1'-biphenyl]-3-yl)sulfonyl]amino]-2-hydroxy-, 2-hydroxyethyl ester | [Molecular Formula]
C21H18FNO7S | [MDL Number]
MFCD32067883 | [MOL File]
1451255-59-6.mol | [Molecular Weight]
447.43 |
| Chemical Properties | Back Directory | [Boiling point ]
680.0±65.0 °C(Predicted) | [density ]
1.507±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 130 mg/mL (290.55 mM) | [form ]
Solid | [pka]
6.42±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1]. | [in vivo]
KAN0438757 (i.p., 10; 25; 50 mg/kg) is well tolerated, and shows no relevant systemic toxic effects in C57BL6/N mice[2].
| [storage]
Store at -20°C | [References]
[1] Gustafsson NMS, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018 Sep 24;9(1):3872. DOI:10.1038/s41467-018-06287-x
[2] De Oliveira T, et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Cancers (Basel). 2021 Feb 28;13(5):1011. DOI:10.3390/cancers13051011 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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