| Identification | Back Directory | [Name]
OP-0595 | [CAS]
1452458-86-4 | [Synonyms]
OP-0595
OP0595 free acid
Sulfuric acid, mono[(1R,2S,5R)-2-[[(2-aminoethoxy)amino]carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester | [Molecular Formula]
C9H16N4O7S | [MDL Number]
MFCD28986228 | [MOL File]
1452458-86-4.mol | [Molecular Weight]
324.31 |
| Chemical Properties | Back Directory | [density ]
1.71±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-4.59±0.18(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Uses]
Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs[1][2]. | [References]
[1] Monogue ML, et al. In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 Aug 27;62(9). DOI:10.1128/AAC.02596-17
[2] Livermore DM, et al. Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases. J Antimicrob Chemother. 2015 Nov;70(11):3032-41. DOI:10.1093/jac/dkv239 |
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| Company Name: |
Advanced chemblocks inc
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650-6922368 650-6922368;650-6922368 |
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https://www.achemblock.com |
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Bide Pharmatech Ltd.
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400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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