| Identification | Back Directory | [Name]
LLP3 | [CAS]
1453835-43-2 | [Synonyms]
LLP3
LLP-3
LLP 3
LLP 3,LLP3
4-(3,5-Bis(benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
4-[3,5-bis(phenylmethoxy)phenyl]-6-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile
3-Pyridinecarbonitrile, 4-[3,5-bis(phenylmethoxy)phenyl]-6-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo- | [Molecular Formula]
C32H23ClN2O4 | [MDL Number]
MFCD28124395 | [MOL File]
1453835-43-2.mol | [Molecular Weight]
534.99 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
DMF: 2 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 2 mg/ml | [form ]
A crystalline solid | [color ]
yellow |
| Hazard Information | Back Directory | [Description]
Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures. | [Uses]
LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM)[1]. | [in vivo]
LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice[1].
| Animal Model: | GBM sphere-derived tumor models (GBM83 and 1600)[1] | | Dosage: | 25 mg/kg | | Administration: | Intraperitoneal injection, for 10 days (days 10–14 and days 17–21) | | Result: |
Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
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| [References]
[1] Hacer Guvenc, et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin Cancer Res. 2013 Feb 1;19(3):631-42. DOI:10.1158/1078-0432.CCR-12-0647 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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