| Identification | Back Directory | [Name]
TP-004 | [CAS]
1454299-21-8 | [Synonyms]
TP-004
TP004,TP 004
3-Pyrrolidinol, 1-[4-methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]-2-pyrimidinyl]-, (3R)- | [Molecular Formula]
C17H16F3N5O | [MDL Number]
MFCD32701911 | [MOL File]
1454299-21-8.mol | [Molecular Weight]
363.34 |
| Chemical Properties | Back Directory | [Boiling point ]
583.2±60.0 °C(Predicted) | [density ]
1.464±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Methanol: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
10.72±0.40(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Uses]
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1]. | [References]
[1] Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26(12), 2774–2778. |
|
|