| Identification | Back Directory | [Name]
2-AMINO-4-CYANO-PHENOL | [CAS]
14543-43-2 | [Synonyms]
2-AMINO-4-CYANO-PHENOL
2-Amino-5-cyano-phenol
5-Cyano-2-hydroxy-aniline
3-Amino-4-hydroxybenzonitrile
Benzonitrile, 3-amino-4-hydroxy-
3-amino-4-hydroxybenzonitrile(SALTDATA: FREE)
5-Cyano-2-hydroxyaniline, 2-Amino-4-cyanophenol
5-Cyano-2-hydroxyaniline, 2-Amino-5-cyanophenol | [Molecular Formula]
C7H6N2O | [MDL Number]
MFCD00234273 | [MOL File]
14543-43-2.mol | [Molecular Weight]
134.14 |
| Chemical Properties | Back Directory | [Melting point ]
151-153℃ | [Boiling point ]
345.1±32.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.63±0.18(Predicted) | [color ]
Brown | [Sensitive ]
Air Sensitive | [Stability:]
Air Sensitive, Light Sensitive | [InChI]
InChI=1S/C7H6N2O/c8-4-5-1-2-7(10)6(9)3-5/h1-3,10H,9H2 | [InChIKey]
ZEWCASRNRWXXSO-UHFFFAOYSA-N | [SMILES]
C(#N)C1=CC=C(O)C(N)=C1 | [CAS DataBase Reference]
14543-43-2 |
| Hazard Information | Back Directory | [Synthesis]
Steps for the synthesis of 3-amino-4-hydroxybenzonitrile: 4-hydroxy-3-nitrobenzonitrile (10 g, 61 mmol) was dissolved in methanol (200 mL) at room temperature and 5% Pd/activated carbon catalyst (0.5 g) was added. Hydrogen was continuously passed into the reaction system via a hydrogen balloon for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 3-amino-4-hydroxybenzonitrile (8.2 g, 100% yield). | [References]
[1] Patent: US6207697, 2001, B1
[2] Patent: US5886044, 1999, A
[3] Patent: US5780483, 1998, A
[4] Patent: US6262113, 2001, B1
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 12, p. 1545 - 1548 |
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