| Identification | Back Directory | [Name]
tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate | [CAS]
1454808-95-7 | [Synonyms]
LP-922761
LP 922761,LP922761
tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate | [Molecular Formula]
C21H26N6O3 | [MOL File]
1454808-95-7.mol | [Molecular Weight]
410.47 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
15.67±0.50(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted. | [in vivo]
In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment[1]. | [storage]
Store at -20°C |
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