| Identification | Back Directory | [Name]
Fmoc-L-Tyr(2-azidoethyl)-OH | [CAS]
1454816-10-4 | [Synonyms]
Fmoc-L-Tyr(2-azidoethyl)-OH
N-Fmoc-O-(2-azidoethyl)-L-tyrosine | [Molecular Formula]
C26H24N4O5 | [MOL File]
1454816-10-4.mol | [Molecular Weight]
472.5 |
| Hazard Information | Back Directory | [Uses]
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | [References]
[1] Jolita Seckute, et al. Rapid oligonucleotide-templated fluorogenic tetrazine ligations. Nucleic Acids Res. 2013 Aug;41(15):e148. DOI:10.1093/nar/gkt540 |
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