| Identification | Back Directory | [Name]
2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)- | [CAS]
1456807-80-9 | [Synonyms]
IMMH004
IMM-H004
IMMH-004
IMM H004
IMMH 004
7-Hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-benzopyran-2-one
2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)-
7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one 2-(2-hydroperoxyethyl)-2-hydroxysuccinate | [Molecular Formula]
C16H20N2O4 | [MDL Number]
MFCD28400900 | [MOL File]
1456807-80-9.mol | [Molecular Weight]
304.34 |
| Hazard Information | Back Directory | [Uses]
IMM-H004, a coumarin derivative, possesses neuroprotective and potent free radical scavenging abilities. IMM-H004 significantly inhibits amyloid-β (Aβ)-induced cytotoxicity and apoptosis, offering potential value for research into neurodegenerative diseases such as Alzheimer's disease. Additionally, IMM-H004 is also capable of effectively blocking the calcium mobilization and chemotaxis induced by CKLF1-C27 (HY-P3418), thereby alleviating asthmatic pathological changes in the lung tissue of CKLF1 transgenic mice[1]. | [References]
[1] Song X Y, et al. IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway[J]. Neuroscience, 2013, 242: 28-38. DOI:10.1016/j.neuroscience.2013.02.049 |
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